Studentship Networks

Immune responses involve interactions between a plethora of different cell types and involve complex intracellular signalling pathways and extra-cellular signals.  Although experimental approaches have provided a great deal of information on the molecular and cellular mechanisms governing outcomes of immune responses, understanding and predicting outcomes of immune responses is extremely complex.  Modelling immune responses and associated signalling pathways utilizing computer simulations and mathematical tools will help determine both rules governing complexity and provide a framework to predict outcomes of immune responses.  These outcomes will be utilized as the basis for further experimentation, creating an iterative experimental and simulation process.  Work undertaken within the network will allow for the evaluation of the various modelling approaches and their applicability (or otherwise) to the modelling of the variety of immunological processes.  This multidisciplinary network includes the following projects:

·         Agent Based Modelling of the NF-κB Pathway

·         Modelling Tumour – NK cell dynamics

·         Stochastic Modelling of the Aging Immune System