Investigating Mitophagy Related Drug Mechanisms in Parkin Mutant Models.

This project aims to elucidate the mechanism by which mitophagy occurs in parkin mutant models with relation to Parkinson’s Disease. Parkinson’s is the second most common neurodegenerative disease and parkin mutations are the most common cause of early onset Parkinson’s. There is no disease modifying therapy in Parkinson’s. Mitophagy is the recycling of dysfunctional mitochondria and of paramount importance to neuronal populations. 

Lead Academic at Lead Institution

Dr Heather Mortiboys – University of Sheffield

Lead Academics at Other Institutions

Dr Chris Elliott -University of York

Dr Ewan Morrison – University of Leeds

Other members of staff involved with this project

Dr Rachael Ivatt -University of Sheffield

Sangeeta Chawla – University of York

Dr Sandra Bell – University of Leeds